Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631478 | 0.77 | MAPT (0.52) | MAPK14KMT2ARAF1GAASMN1; SMN2 | |
| SCHEMBL937764 | 0.74 | RAF1 (0.66) | MAPK14RAF1SMN1; SMN2MAPTKDR | |
| SCHEMBL20166866 | 0.72 | CYP1A2 (0.51) | MAPK14SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL3669020 | 0.72 | CYP1A2 (0.51) | MAPK14SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL11253369 | 0.69 | CYP1A2 (0.44) | MAPK14KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL18666165 | 0.66 | ADRA2C (0.78) | KMT2AGAASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL937763 | 0.64 | RAF1 (0.70) | MAPK14RAF1LMNAKDR | |
| SCHEMBL6378842 | 0.64 | KMT2A (0.53) | MAPK14KMT2AGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL667449 | 0.63 | RAF1 (0.80) | MAPK14RAF1KDR | |
| SCHEMBL938751 | 0.63 | RAF1 (0.80) | MAPK14RAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4403482-B2 | — | — | 2010-01-27 | — | — | JP | claimed |
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | claimed |
| JP-2001526223-A | — | — | 2001-12-18 | — | — | JP | claimed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | claimed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | claimed |