Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163681 | 0.80 | MEN1 (0.44) | PARP1MEN1KMT2APOLB | |
| SCHEMBL4004339 | 0.79 | KCNK3 (0.76) | PARP1PARP10PARP15MEN1KMT2A | |
| SCHEMBL29835051 | 0.77 | PARP1 (0.53) | PARP1PARP10PARP15MEN1KMT2A | |
| SCHEMBL3637225 | 0.77 | TYK2 (0.73) | PARP1PARP10PARP15MEN1KMT2A | |
| SCHEMBL15901904 | 0.76 | NPC1 (0.61) | MEN1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL28031075 | 0.76 | KCNK3 (0.77) | MEN1KMT2APLAUPOLBKCNK3 | |
| SCHEMBL3069463 | 0.76 | PLAU (0.76) | PARP1PARP10PARP15MEN1KMT2A | |
| SCHEMBL28155028 | 0.75 | KMT2A (0.61) | PARP1PARP10PARP15MEN1KMT2A | |
| SCHEMBL21446860 | 0.74 | PLAU (0.78) | MEN1KMT2APLAUSIRT2 | |
| SCHEMBL19303149 | 0.74 | KMT2A (0.59) | PARP1PARP10PARP15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | claimed |
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | disclosed |