SCHEMBL28031075

SCHEMBL28031075

NC(=O)c1cccc(C(=O)Nc2cccc(NC(=O)c3ccccc3)c2)c1

nearest known ligand 0.77

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 9/20 0.77
KCNK9 Q9NPC2 7/20 0.77
SIRT1 Q96EB6 1/20 0.68
MEN1 O00255 5/20 0.67
KMT2A Q03164 5/20 0.67
POLB P06746 1/20 0.67
PLAU P00749 1/20 0.67
SIRT2 Q8IXJ6 1/20 0.65
TP53 P04637 1/20 0.64
HDAC1 Q13547 1/20 0.63
HDAC2 Q92769 1/20 0.63
HDAC8 Q9BY41 1/20 0.63
HDAC6 Q9UBN7 1/20 0.63
NPC1 O15118 2/20 0.61
RAB9A P51151 2/20 0.61
HPGD P15428 1/20 0.61
ALDH1A1 P00352 1/20 0.59
MAPT P10636 1/20 0.59
LPAR3 Q9UBY5 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3069463 0.93 PLAU (0.76) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL4004339 0.93 KCNK3 (0.76) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL28031074 0.92 PLAU (0.69) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715827 0.91 KCNK3 (0.92) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715912 0.88 KCNK3 (0.92) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715821 0.88 KCNK3 (0.85) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL2298254 0.88 KCNK3 (1.00) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL11882113 0.87 PTGS1 (0.59) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL7739117 0.86 KCNK3 (0.82) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL10090679 0.86 PARP1 (0.74) KCNK3KCNK9SIRT1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103764793-B High flow liquid crystalline polymer composition 提克纳有限责任公司 2016-09-14 CN disclosed
CN-103764623-B Aromatic amide compounds TICONA LLC (US) 2016-04-27 CN disclosed
CN-103764741-B The melt polymerization of low melt viscosity liquid crystalline polymers TICONA LLC (US) 2015-09-23 CN disclosed