Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625466 | 0.84 | LMNA (0.53) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL3633781 | 0.83 | LMNA (0.52) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL3627572 | 0.83 | LMNA (0.52) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL1735675 | 0.82 | MAPT (0.56) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL1735673 | 0.82 | MAPT (0.56) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL3630086 | 0.81 | LMNA (0.51) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL3629777 | 0.81 | LMNA (0.51) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL1734635 | 0.81 | MAPT (0.56) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL1734636 | 0.81 | MAPT (0.56) | LMNAMAPTUSP2L3MBTL1TP53 | |
| SCHEMBL1737114 | 0.80 | LMNA (0.64) | LMNAMAPTUSP2L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | claimed |
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |