Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274051 | 0.96 | GSK3B (0.47) | GSK3BCYP1A2CYP2D6CSNK1A1GSK3A | |
| SCHEMBL3277629 | 0.94 | CYP3A4 (0.47) | NPC1RAB9AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL3279276 | 0.83 | GSK3B (0.48) | GSK3BCYP1A2CYP2D6CSNK1A1GSK3A | |
| SCHEMBL3273306 | 0.81 | GSK3B (0.50) | GSK3BCYP1A2CYP2D6CYP3A4MEN1 | |
| SCHEMBL3280874 | 0.79 | ROCK2 (0.51) | GSK3BCYP1A2CYP2D6CSNK1A1GSK3A | |
| SCHEMBL3273879 | 0.77 | GSK3B (0.43) | GSK3BCYP1A2CYP2D6CSNK1A1GSK3A | |
| SCHEMBL3273287 | 0.76 | POLB (0.52) | POLBRAB9AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL3273968 | 0.76 | GSK3B (0.52) | GSK3BCYP1A2CYP2D6CSNK1A1GSK3A | |
| SCHEMBL3273819 | 0.76 | GAA (0.53) | NPC1RAB9AGSK3BCYP1A2CYP2D6 | |
| SCHEMBL3274517 | 0.75 | ROCK2 (0.48) | GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148866-A2 | ARYLAMIDE PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Sanofi-Aventis (FR) | 2010-02-03 | — | — | EP | claimed |
| WO-2008155669-A2 | ARYLAMIDE PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI-AVENTIS (FR) | 2008-12-24 | — | — | WO | claimed |