Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631068 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1HRH3PARP1 | |
| SCHEMBL1018369 | 0.79 | PARP1 (0.44) | KDM4EALDH1A1HRH3PARP1 | |
| SCHEMBL3770129 | 0.78 | ALDH1A1 (0.80) | KDM4EALDH1A1ACHEHRH3PARP1 | |
| SCHEMBL3631066 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1ACHEHRH3PARP1 | |
| SCHEMBL969808 | 0.75 | TSHR (0.50) | KDM4EALDH1A1PARP1HTTSMN1; SMN2 | |
| SCHEMBL1015263 | 0.74 | HTT (0.44) | KDM4EALDH1A1HRH3PARP1HTT | |
| SCHEMBL3772641 | 0.73 | ALDH1A1 (0.69) | KDM4EALDH1A1ACHEHRH3PARP1 | |
| SCHEMBL13005789 | 0.72 | KDM4E (0.64) | KDM4EALDH1A1ACHEHRH3ACACB | |
| SCHEMBL3765810 | 0.72 | ALDH1A1 (0.67) | KDM4EALDH1A1ACHEHRH3SMN1; SMN2 | |
| SCHEMBL1017261 | 0.71 | PARP1 (0.43) | KDM4EALDH1A1HRH3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795262-B2 | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues | NEUROGEN CORPORATION (US) | 2010-09-14 | — | — | US | disclosed |
| US-20070232591-A1 | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues | NEUROGEN CORPORATION | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232591-A1 | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues | HRH3, HRH4, HRH1 | KDM4E 2634/4885ALDH1A1 1229/4885ACHE 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.