⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813367 | 0.80 | — | — | |
| SCHEMBL8850882 | 0.78 | — | — | |
| SCHEMBL16398665 | 0.78 | — | — | |
| SCHEMBL8850887 | 0.78 | — | — | |
| SCHEMBL9659240 | 0.76 | CYP3A4 (0.34) | — | |
| SCHEMBL9110 | 0.76 | — | — | |
| SCHEMBL4845914 | 0.76 | — | — | |
| SCHEMBL27863012 | 0.75 | DNM1 (0.41) | — | |
| SCHEMBL8735467 | 0.74 | — | — | |
| SCHEMBL16553916 | 0.73 | DNM1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110298-A1 | HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2023-01-04 | — | — | EP | disclosed |
| WO-2021133817-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES | Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) | 2021-07-01 | — | — | WO | disclosed |
| WO-2020140005-A2 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-07-02 | — | — | WO | disclosed |
| WO-2020041406-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020041405-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2020-02-27 | — | — | WO | disclosed |
| EP-2142555-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119663-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |
| EP-0441807-A1 | LIQUID PHASE FLUORINATION. | EXFLUOR RES CORP (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0436669-A1 | PERFLUOROACETAL AND PERFLUOROKETAL COMPOUNDS AND USE THEREOF IN THERMAL SHOCK TESTING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1991-07-17 | — | — | EP | disclosed |