Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621162 | 0.90 | HTR2C (0.46) | HTR2CHRH4HRH3KCNH2HRH1 | |
| SCHEMBL1775878 | 0.66 | HRH4 (0.52) | HRH4HRH3KCNH2 | |
| SCHEMBL1698371 | 0.65 | HTR2C (0.61) | HTR2CHRH4 | |
| SCHEMBL17822440 | 0.63 | HRH4 (0.56) | HRH4HRH3KCNH2 | |
| SCHEMBL3621158 | 0.63 | HRH3 (0.39) | HTR2CHRH4HRH3KCNH2 | |
| SCHEMBL1026755 | 0.63 | HTR2C (1.00) | HTR2C | |
| Hydrazine SCHEMBL9427083 | 0.63 | HRH4 (0.43) | HTR2CHRH4HRH3KCNH2HRH1 | |
| SCHEMBL30297584 | 0.63 | HTR2C (1.00) | HTR2C | |
| SCHEMBL2567450 | 0.63 | HRH4 (0.55) | HRH4HRH3KCNH2HRH1 | |
| SCHEMBL1698424 | 0.62 | HTR2C (0.57) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674907-B2 | Furanopyridine derivatives and methods of use | AMGEN INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | AMGEN INC. | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | LCK, NFATC1, MINK1 | HTR2C 2774/4885HRH4 549/4885HRH3 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.