Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.76 |
| ▸ | MAPKAPK2 | P49137 | 13/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231573 | 0.86 | CDC7 (1.00) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL16872486 | 0.85 | CDC7 (0.97) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| SCHEMBL3574892 | 0.84 | CDC7 (0.85) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| SCHEMBL3583945 | 0.79 | MAPKAPK2 (0.62) | CDC7MAPKAPK2MAPK9 | |
| SCHEMBL3584751 | 0.78 | MAPKAPK2 (0.69) | CDC7MAPKAPK2MAPK9 | |
| SCHEMBL3225560 | 0.78 | CDC7 (0.68) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| SCHEMBL3222669 | 0.77 | CDC7 (0.60) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| Trifluoroacetic Acid SCHEMBL4257307 | 0.77 | CDC7 (0.80) | CDC7MAPKAPK2MAPK9CDK4CCND1 | |
| SCHEMBL3222565 | 0.75 | CDC7 (0.57) | CDC7AURKADAPK3JAK2ROCK2 | |
| SCHEMBL3224703 | 0.75 | CDC7 (0.57) | CDC7MAPKAPK2MAPK9CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | disclosed |
| EP-2064212-A1 | PYRROLO ISOQUINOLINES AS KINASE INHIBITORS | Novartis AG (CH) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008025512-A1 | PYRROLO ISOQUINOLINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | SLCO1B3, CYP3A7, SLCO1B1 | CDC7 3142/4885MAPKAPK2 4563/4885MAPK9 2834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.