Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14830903 | 0.75 | CYP17A1 (0.53) | CYP17A1CYP1A2 | |
| SCHEMBL3632409 | 0.72 | ATR (0.36) | PRKCICYP1A2SCN9AMEN1KMT2A | |
| SCHEMBL593790 | 0.72 | PRKCI (0.33) | LIMK1PRKCIADORA2AADORA2BCYP17A1 | |
| SCHEMBL594951 | 0.72 | PRKCI (0.38) | LIMK1PRKCICYP17A1CYP1A2SCN9A | |
| SCHEMBL3632602 | 0.72 | GRK2 (0.36) | CYP17A1CYP1A2SCN9AKDM4EMAPK8 | |
| SCHEMBL391300 | 0.72 | CACNA2D1 (0.34) | CYP17A1SCN9AMAPK8MAPK9MAPK10 | |
| SCHEMBL3627327 | 0.72 | GPBAR1 (0.37) | USP2 | |
| SCHEMBL593920 | 0.71 | CYP2A6 (0.55) | CYP17A1CYP1A2SCN9AMAPTHSD17B10 | |
| SCHEMBL388931 | 0.69 | CYP2A6 (0.42) | CYP17A1CYP1A2SCN9AKMT2APDE4B | |
| SCHEMBL3627332 | 0.69 | TRPV1 (0.37) | ADORA2AADORA1ADORA2BSCN9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155735-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008144222-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-11-27 | — | — | WO | disclosed |