SCHEMBL3632602

SCHEMBL3632602

OCCc1cnccc1-c1cccc2ccsc12

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GRK2 P25098 1/20 0.36
TNF P01375 2/20 0.34
GPBAR1 Q8TDU6 1/20 0.34
CYP19A1 P11511 2/20 0.33
TKT P29401 1/20 0.33
CYP2A6 P11509 2/20 0.33
SCN9A Q15858 1/20 0.32
CYP17A1 P05093 1/20 0.32
CYP1A2 P05177 1/20 0.32
ATR Q13535 1/20 0.32
FEN1 P39748 1/20 0.31
MAPK8 P45983 2/20 0.31
MAPK9 P45984 2/20 0.31
MAPK10 P53779 2/20 0.31
KDM4E B2RXH2 1/20 0.30
MAPKAPK2 P49137 1/20 0.30
NAMPT P43490 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3632409 0.86 ATR (0.36) TNFGPBAR1CYP19A1CYP2A6SCN9A
SCHEMBL3627332 0.82 TRPV1 (0.37) SCN9AFEN1MAPK8MAPK9MAPK10
SCHEMBL593790 0.73 PRKCI (0.33) TNFCYP2A6SCN9ACYP17A1CYP1A2
SCHEMBL388931 0.73 CYP2A6 (0.42) TNFCYP2A6SCN9ACYP17A1CYP1A2
SCHEMBL14830903 0.73 CYP17A1 (0.53) CYP17A1CYP1A2
SCHEMBL593920 0.72 CYP2A6 (0.55) TNFCYP19A1CYP2A6SCN9ACYP17A1
SCHEMBL3632407 0.72 AOC1 (0.40) CYP2A6SCN9ACYP17A1CYP1A2MAPK8
SCHEMBL594951 0.70 PRKCI (0.38) TNFCYP2A6SCN9ACYP17A1CYP1A2
SCHEMBL3627327 0.70 GPBAR1 (0.37) GPBAR1CYP19A1
SCHEMBL391300 0.70 CACNA2D1 (0.34) TNFSCN9ACYP17A1ATRMAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155735-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2010-02-24 EP disclosed
WO-2008144222-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2008-11-27 WO disclosed