Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.61 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974684 | 0.86 | KDM4E (0.47) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2418742 | 0.82 | MAPK14 (0.59) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2420478 | 0.75 | GRIK1 (0.59) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4603074 | 0.74 | GRIK1 (0.62) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL17403498 | 0.74 | GRIK1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL21900280 | 0.73 | GRIA1 (0.84) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL22295786 | 0.72 | GRIK1 (0.55) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL395863 | 0.72 | MAPK14 (0.57) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL394810 | 0.71 | MAPK14 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2744390 | 0.71 | GRIK1 (0.59) | GRIK1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144881-B1 | ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |
| EP-2144881-A1 | ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA | AstraZeneca AB (SE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008122765-A1 | NEW COMPOUNDS AND THEIR USES 707 | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | WO | disclosed |