Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SCN1A | P35498 | 2/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29500191 | 1.00 | TSHR (0.67) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL15907643 | 0.94 | ALDH1A1 (0.68) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL2137523 | 0.90 | TSHR (0.73) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL8873461 | 0.87 | TSHR (0.65) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL29500171 | 0.86 | TSHR (0.65) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL3230316 | 0.86 | TSHR (0.65) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL14557460 | 0.86 | TSHR (0.83) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL5893357 | 0.85 | TSHR (0.73) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL3628418 | 0.85 | TSHR (0.61) | TSHRTDP1L3MBTL1CYP3A4MAPK1 | |
| SCHEMBL3631447 | 0.85 | TSHR (0.61) | TSHRTDP1L3MBTL1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114436833-A | Preparation method of telmisartan key intermediate 4' -methylbiphenyl-2-carboxylic ester | 南京红太阳医药研究院有限公司 | 2022-05-06 | — | — | CN | disclosed |
| EP-2146963-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008133896-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-5166206-A | Hypotensive agents, central nervous system disorders, glaucoma or angiotensin antagonist | MERCK & CO., INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |