Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101936 | 0.85 | SSTR5 (0.50) | SSTR5KCNH2SSTR3 | |
| SCHEMBL3876136 | 0.82 | SSTR5 (0.58) | SSTR5KCNH2SSTR3 | |
| SCHEMBL3104473 | 0.77 | SSTR5 (0.48) | SSTR5KCNH2 | |
| SCHEMBL20456419 | 0.76 | CXCR3 (0.47) | — | |
| SCHEMBL3633329 | 0.73 | HRH3 (0.46) | SSTR5KCNH2ALDH1A1 | |
| SCHEMBL3634990 | 0.72 | SSTR5 (0.59) | SSTR5KCNH2HRH1 | |
| SCHEMBL3633858 | 0.71 | SSTR5 (0.55) | SSTR5HRH1 | |
| SCHEMBL669387 | 0.71 | GRM2 (0.53) | SSTR5KDM4EALDH1A1KMT2A | |
| SCHEMBL2965998 | 0.71 | SSTR5 (0.72) | SSTR5KCNH2 | |
| SCHEMBL3095201 | 0.70 | SCN1A (0.52) | SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008122510-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-16 | — | — | WO | claimed |
| EP-2142528-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008122510-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-16 | — | — | WO | disclosed |