Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369870 | 0.81 | PDE10A (0.64) | PDE10ATP53TSHRALDH1A1 | |
| SCHEMBL363611 | 0.80 | PDE10A (0.62) | PDE10ATP53TSHRPOLBTDP1 | |
| SCHEMBL362925 | 0.76 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363902 | 0.75 | PDE10A (0.67) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL10099716 | 0.72 | EGFR (0.46) | PDE10AEGFRTSHRPOLBKDM4E | |
| SCHEMBL362066 | 0.72 | MAPT (0.48) | PDE10ATP53TSHRPOLBTDP1 | |
| SCHEMBL9672668 | 0.66 | PDE7A (0.70) | TSHRPDE7BALDH1A1 | |
| SCHEMBL10546745 | 0.64 | CYSLTR2 (0.50) | PDE10APOLBKDM4E | |
| SCHEMBL8776755 | 0.61 | TSHR (0.58) | PDE10ATP53TSHRTDP1KDM4E | |
| SCHEMBL8547224 | 0.61 | PDE10A (0.48) | PDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |