Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | PKM | P14618 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363347 | 0.81 | PDE10A (0.61) | PDE10AALDH1A1TSHRTP53 | |
| SCHEMBL370737 | 0.78 | PDE10A (1.00) | PDE10ASMN1; SMN2RAB9ANPC1DAPK3 | |
| SCHEMBL363611 | 0.76 | PDE10A (0.62) | PDE10ASMN1; SMN2PKMRAB9ANPC1 | |
| SCHEMBL10099716 | 0.69 | EGFR (0.46) | PDE10ASMN1; SMN2PIM1ALDH1A1TSHR | |
| SCHEMBL363615 | 0.69 | PDE10A (0.48) | PDE10ASMN1; SMN2ALDH1A1TSHRMEN1 | |
| SCHEMBL362066 | 0.69 | MAPT (0.48) | PDE10AALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL16998660 | 0.65 | RAB9A (0.68) | PDE10ASMN1; SMN2PKMRAB9ANPC1 | |
| SCHEMBL259118 | 0.64 | PDE10A (1.00) | PDE10ASMN1; SMN2PKMRAB9ANPC1 | |
| SCHEMBL369760 | 0.64 | PDE10A (1.00) | PDE10APKMNPC1ALDH1A1LMNA | |
| SCHEMBL4725310 | 0.64 | NPC1 (1.00) | SMN1; SMN2PKMRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |