Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 3/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634094 | 0.87 | MDM2 (0.34) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL3630824 | 0.86 | KMT2A (0.36) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL3630762 | 0.85 | KMT2A (0.45) | KMT2ANPC1RAB9AMEN1EGFR | |
| SCHEMBL3633099 | 0.84 | CHRNA7 (0.40) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL3942557 | 0.83 | EGFR (0.32) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL3636515 | 0.82 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2MDM2GRM5 | |
| SCHEMBL3635507 | 0.80 | ABL1 (0.34) | KMT2ATNFBCL6MDM2EGFR | |
| SCHEMBL27800296 | 0.71 | MAPT (0.45) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL847910 | 0.69 | KMT2A (0.43) | KCNQ3KCNQ2KMT2ANPC1RAB9A | |
| SCHEMBL846959 | 0.69 | FFAR1 (0.40) | KMT2ANPC1RAB9ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |