Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800314 | 0.81 | TRPV1 (0.46) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL27800307 | 0.80 | ABCG2 (0.49) | MAPTSMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL27779942 | 0.78 | RAB9A (0.35) | MAPTTP53ALDH1A1RAB9ANPC1 | |
| SCHEMBL27800317 | 0.78 | DHODH (0.56) | MAPTSMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL8171612 | 0.75 | DHODH (0.57) | MAPTTP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL846982 | 0.74 | MAPT (0.44) | MAPTTP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL27917422 | 0.73 | IRAK4 (0.38) | ALDH1A1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL10169191 | 0.73 | MAPK8 (0.54) | MAPTSMN1; SMN2KMT2ARAB9ANPC1 | |
| SCHEMBL3636515 | 0.72 | KDM4E (0.41) | MAPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL12715339 | 0.72 | MAPT (0.54) | MAPTTP53SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679270-B | Dihydroquinone and dihydronaphthyridine inhibitors of JNK | HOFFMANN LA ROCHE | 2013-05-01 | — | — | CN | disclosed |
| CN-101679270-A | Dihydroquinone and dihydronaphthyridine inhibitors of JNK | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |