SCHEMBL3633753

SCHEMBL3633753

COc1ccc(C(CCCOc2ccccc2)N2Cc3c(cccc3N3CCN(C4CC4)CC3)C2=O)cc1OC

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2341376 1.00 UTS2R (0.66) UTS2R
SCHEMBL2346047 0.89 UTS2R (0.68) UTS2R
SCHEMBL2346051 0.88 UTS2R (0.65) UTS2R
SCHEMBL3633774 0.88 UTS2R (0.59) UTS2R
SCHEMBL2346840 0.88 UTS2R (0.59) UTS2R
SCHEMBL3634257 0.88 UTS2R (0.68) UTS2R
SCHEMBL3634258 0.88 UTS2R (0.68) UTS2R
SCHEMBL3634254 0.85 UTS2R (0.65) UTS2R
SCHEMBL3636429 0.85 UTS2R (0.68) UTS2R
SCHEMBL3636428 0.85 UTS2R (0.68) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2161994-A2 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2010-03-17 EP claimed
WO-2008153902-A2 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA, N.V. (BE) 2008-12-18 WO claimed