Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL19585410 | 0.97 | CA4 (0.46) | CA4ALDH1A1KDM4ELMNAMAPT | |
| Water SCHEMBL17843652 | 0.94 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| Potassium Ion SCHEMBL1389321 | 0.92 | ALDH1A1 (0.48) | CA4ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL149815 | 0.92 | ALDH1A1 (0.48) | CA4ALDH1A1KDM4ELMNAMAPT | |
| Water SCHEMBL28741257 | 0.91 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| Water SCHEMBL7558083 | 0.91 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL27748681 | 0.91 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| Potassium Ion SCHEMBL12980475 | 0.91 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL1938661 | 0.91 | ALDH1A1 (0.47) | CA4ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL29234711 | 0.89 | CA4 (0.55) | CA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101715350-A | Strontium fortified calcium nanoparticle and microparticle compositions and methods of making and using the same | UNIV HONG KONG | 2010-05-26 | — | — | CN | disclosed |
| EP-2164533-A1 | STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | The University of Hong Kong (CN) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009000158-A1 | STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | THE UNIVERSITY OF HONG KONG (CN) | 2008-12-31 | — | — | WO | disclosed |
| US-20080317807-A1 | STRONTIUM FORTIFIED CALCIUM NANO-AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | THE UNIVERSITY OF HONG KONG | 2008-12-25 | — | — | US | disclosed |