Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.52 |
| ▸ | PGR | P06401 | 3/20 | 0.52 |
| ▸ | SHBG | P04278 | 3/20 | 0.52 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628231 | 0.87 | CYP19A1 (0.61) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL3330736 | 0.86 | CYP19A1 (0.60) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL3633040 | 0.85 | CYP19A1 (0.65) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL674222 | 0.84 | CYP3A4 (0.71) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL7992724 | 0.84 | CYP3A4 (0.71) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL23748331 | 0.84 | CYP3A4 (0.71) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL4747201 | 0.84 | CYP3A4 (0.71) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL6053061 | 0.82 | CYP19A1 (0.66) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL15528759 | 0.82 | PSEN1 (0.61) | ALDH1A1LMNACYP3A4SMN1; SMN2MAPT | |
| SCHEMBL13752819 | 0.78 | CYP19A1 (0.72) | LMNACYP3A4MAPTCYP19A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142194-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | N.V. Organon (NL) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119918-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | N.V. ORGANON (NL) | 2008-10-09 | — | — | WO | disclosed |