Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | SHBG | P04278 | 4/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | AR | P10275 | 4/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.52 |
| ▸ | PGR | P06401 | 3/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3330736 | 0.91 | CYP19A1 (0.60) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3633040 | 0.89 | CYP19A1 (0.65) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3634099 | 0.87 | ALDH1A1 (0.61) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23748331 | 0.85 | CYP3A4 (0.71) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4747201 | 0.85 | CYP3A4 (0.71) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6053061 | 0.85 | CYP19A1 (0.66) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7992724 | 0.85 | CYP3A4 (0.71) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL674222 | 0.85 | CYP3A4 (0.71) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL18891474 | 0.84 | LMNA (0.78) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9540733 | 0.84 | LMNA (0.78) | CYP19A1CYP3A4LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142194-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | N.V. Organon (NL) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119918-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | N.V. ORGANON (NL) | 2008-10-09 | — | — | WO | disclosed |