Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 5/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29704539 | 0.78 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2935836 | 0.78 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL1149876 | 0.77 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3673783 | 0.77 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL13938761 | 0.74 | CYP1A2 (0.71) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3634558 | 0.74 | TAAR1 (0.45) | IDO1TAAR1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL515041 | 0.73 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL22430855 | 0.73 | IDO1 (0.56) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL4264261 | 0.73 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL9976780 | 0.73 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2160396-B1 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | AGILENT TECHNOLOGIES INC (US) | 2018-11-21 | — | — | EP | disclosed |
| EP-2476689-B1 | Thiocarbon-protecting groups for RNA synthesis | AGILENT TECHNOLOGIES INC (US) | 2015-10-21 | — | — | EP | disclosed |
| US-9067961-B2 | Thiocarbon-protecting groups for RNA synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20120238737-A1 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | AGILENT TECHNOLOGIES, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| EP-2476689-A1 | Thiocarbon-protecting groups for RNA synthesis | Agilent Technologies, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |
| US-8202983-B2 | Thiocarbon-protecting groups for RNA synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| EP-2160396-A2 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | Agilent Technologies, Inc. (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20090209479-A1 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | AGILENT TECHNOLOGIES, INC. | 2009-08-20 | — | — | US | disclosed |
| WO-2008141248-A2 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | AGILENT TECHNOLOGIES, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238737-A1 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | NSUN3, NSUN2, TRDMT1 | CYP1A2 4005/4885CYP3A4 3732/4885CYP2C19 4284/4885 |
| US-20090209479-A1 | THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS | NSUN3, NSUN2, TRDMT1 | CYP1A2 4005/4885CYP3A4 3732/4885CYP2C19 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.