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Sugi Predict / Targets / TRDMT1

TRDMT1

tRNA (cytosine(38)-C(5))-methyltransferase · O14717 · TRDMT1 on Sugi Atlas →

1,945 patent compounds predicted against TRDMT1, 1,636 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9970210 SCHEMBL9970210 0.52 7/20
SCHEMBL505843 SCHEMBL505843 0.75 6/20
SCHEMBL4319361 SCHEMBL4319361 0.75 6/20
SCHEMBL4319379 SCHEMBL4319379 0.75 6/20
SCHEMBL9940362 SCHEMBL9940362 0.47 6/20
SCHEMBL9970608 SCHEMBL9970608 0.49 5/20
SCHEMBL9970615 SCHEMBL9970615 0.49 5/20
SCHEMBL10061380 SCHEMBL10061380 0.48 5/20
SCHEMBL9937206 SCHEMBL9937206 0.48 5/20
SCHEMBL9940922 SCHEMBL9940922 0.48 5/20
SCHEMBL9940838 SCHEMBL9940838 0.48 5/20
SCHEMBL9970699 SCHEMBL9970699 0.48 5/20
SCHEMBL469241 SCHEMBL469241 0.80 4/20
SCHEMBL805652 SCHEMBL805652 0.72 4/20
SCHEMBL2288235 SCHEMBL2288235 0.67 4/20
SCHEMBL2288248 SCHEMBL2288248 0.67 4/20
SCHEMBL2288255 SCHEMBL2288255 0.67 4/20
SCHEMBL9940623 SCHEMBL9940623 0.51 4/20
SCHEMBL9970620 SCHEMBL9970620 0.51 4/20
SCHEMBL9937164 SCHEMBL9937164 0.47 4/20

Clinical trials — most relevant to TRDMT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema PHASE2COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Nucleoside Therapy in Patients With Telomere Biology Disorders PHASE1RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma nanCOMPLETED
MicroRNAs and Cytokines in Peri-Implantitis Tissue nanUNKNOWN
X-chromosome Inactivation, Epigenetics and the Transcriptome nanCOMPLETED
Search for Bovine miRNA Transference to Humans nanCOMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer nanUNKNOWN
Diagnosis of Inflammatory Bowel Disease nanNOT_YET_RECRUITING
Prognosis of METTL-14 in Endometrial Carcinoma nanNOT_YET_RECRUITING
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB) nanCOMPLETED
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer nanUNKNOWN
Venous Thromboembolism in Myotonic Dystrophy Type 1 nanCOMPLETED
Research on the Early and Prognosis Diagnosis of Vascular Dementia nanRECRUITING
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans nanACTIVE_NOT_RECRUITING
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study nanNOT_YET_RECRUITING
Vascular Senescence and Atherosclerotic Plaque Vulnerability nanRECRUITING
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
Patient's Derived Organoids for Drug Screening in Glioblastoma nanNOT_YET_RECRUITING
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Effects of Fecal Microbiota Transplantation on Weight in Obese Patients With Non-alcoholic Fatty Liver Disease nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRDMT1 binder may also engage these)

ProteinNameSimilarity
Q7YS61 — 1.000 Q7YS61 →
O55055 — 0.995 O55055 →
Q4G073 — 0.991 Q4G073 →
Q6GR37 — 0.966 Q6GR37 →
Q6GQ33 — 0.960 Q6GQ33 →
Q6NYU2 — 0.960 Q6NYU2 →
Q14CH1 — 0.958 Q14CH1 →
Q1HFZ0 — 0.957 Q1HFZ0 →
Q5F480 — 0.956 Q5F480 →
Q8NFZ0 — 0.955 Q8NFZ0 →
NSUN2 RNA cytosine C(5)-methyltransferase NSUN2 0.955 landscape →
Q96EN8 — 0.955 Q96EN8 →
A6NJ78 — 0.955 A6NJ78 →
Q6DFV5 — 0.955 Q6DFV5 →
Q9H5U6 — 0.954 Q9H5U6 →
Q5R962 — 0.954 Q5R962 →
Q6DC64 — 0.954 Q6DC64 →
HELZ Probable helicase with zinc finger domain 0.954 landscape →
Q9UBK8 — 0.953 Q9UBK8 →
D3ZV31 — 0.953 D3ZV31 →
E1BGQ2 — 0.953 E1BGQ2 →
Q6PF06 — 0.952 Q6PF06 →
Q7SY78 — 0.952 Q7SY78 →
Q8BKW4 — 0.951 Q8BKW4 →
Q9CWH5 — 0.951 Q9CWH5 →
Q08DP1 — 0.951 Q08DP1 →
Q5ZIA0 — 0.951 Q5ZIA0 →
Q0V8R7 — 0.951 Q0V8R7 →
G1SPE9 — 0.951 G1SPE9 →
PARN Poly(A)-specific ribonuclease PARN 0.950 landscape →