Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30993835 | 0.92 | GPBAR1 (0.49) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL3333554 | 0.92 | GPBAR1 (0.49) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL3337083 | 0.80 | GPBAR1 (0.53) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL30993882 | 0.80 | GPBAR1 (0.53) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL30509067 | 0.77 | GPBAR1 (0.46) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL3336075 | 0.77 | GPBAR1 (0.46) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL3337496 | 0.77 | HSD17B1 (0.46) | GPBAR1ALDH1A1 | |
| SCHEMBL3337095 | 0.76 | S1PR4 (0.39) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL3337987 | 0.75 | GPBAR1 (0.46) | GPBAR1MAPTPOLBGAARECQL | |
| SCHEMBL30509079 | 0.75 | GPBAR1 (0.46) | GPBAR1MAPTPOLBGAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155194-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124610-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |