SCHEMBL363477

SCHEMBL363477

O=C=NCC(F)(F)F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7872904 0.81
SCHEMBL1984502 0.81
SCHEMBL1988523 0.77
SCHEMBL6363774 0.77
SCHEMBL2048936 0.77
SCHEMBL2049127 0.77
SCHEMBL6366858 0.77
SCHEMBL26555219 0.76
SCHEMBL4806856 0.75
SCHEMBL4810017 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116640080-A Preparation method of N- [ (2, 2-trifluoroethyl) amino ] pyrrolidinyl compound 福建永晶科技股份有限公司 2023-08-25 CN claimed
US-11282710-B2 Selective deposition on silicon containing surfaces VERSUM MATERIALS US, LLC (US) 2022-03-22 US claimed
EP-0630382-B1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY ZENECA LTD (GB) 1997-02-26 EP claimed
EP-0630382-A1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY. ZENECA LTD (GB) 1994-12-28 EP claimed
WO-1993021212-A1 LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY ZENECA LIMITED (GB) 1993-10-28 WO claimed
EP-4727537-A2 SIGLEC LIGANDS, CONJUGATES, AND METHODS OF USE THEREOF Adaxion Therapeutics, Inc. (US) 2026-04-22 EP disclosed
US-12552767-B2 3-heteroaryl pyrrolidine and piperidine orexin receptor agonists MERCK SHARP & DOHME LLC (US) 2026-02-17 US disclosed
US-12492204-B2 Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors CHEMWERTH, INC. (US) 2025-12-09 US disclosed
EP-4630115-A1 THERAPEUTIC COMPOUNDS Sanofi (FR) 2025-10-15 EP disclosed
EP-3727380-B1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA MERCK SHARP & DOHME LLC (US) 2025-09-24 EP disclosed
US-20250243208-A1 BICYCLIC HETEROCYCLES AS MRGPRX2 ANTAGONISTS INCYTE CORPORATION 2025-07-31 US disclosed
US-20250228239-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-07-17 US disclosed
US-4624981-A Process for the production of polyamideimides from polyisocyanates, polycarboxylic acid anhydrides and lactams or polyamides in which the reaction products are precipitated with a non-solvent BAYER AKTIENGESELLSCHAFT 1986-11-25 US disclosed
US-4600729-A Process for the preparation of aliphatic-aromatic poly-amide-imides in the absence of phenols BAYER AKTIENGESELLSCHAFT (DE) 1986-07-15 US disclosed
US-4548970-A Polyamideimides prepared by reacting either lactams or polyamides with polyisocyanates and anhydrides using a lactam as an additive BAYER AKTIENGESELLSCHAFT (DE) 1985-10-22 US disclosed
EP-0157139-A2 Process for the phenol-free preparation of aromatic-aliphatic polyamide imides BAYER AG (DE) 1985-10-09 EP disclosed
US-4546138-A Process for the production of polyamide imides by using a phenol in the workup of the material BAYER AKTIENGESELLSCHAFT (DE) 1985-10-08 US disclosed
US-4092475-A ANTIBIOTICS E. R. SQUIBB & SONS, INC. (US) 1978-05-30 US disclosed
US-3965074-A Homopolymers of polyfluorinated vinyl isocyanates E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-06-22 US disclosed
US-3943112-A PERFLUORINATED VINYL ISOCYANATE COPOLYMERS; OIL AND WATER REPELLENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-03-09 US disclosed