Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28389494 | 0.82 | HTT (0.47) | HTTGAAALDH1A1CYP1A2KDM4E | |
| SCHEMBL22064104 | 0.81 | HTT (0.52) | HTTGAAALDH1A1CYP1A2KDM4E | |
| SCHEMBL12405746 | 0.80 | HTT (0.60) | HTTGAAALDH1A1CYP1A2KDM4E | |
| SCHEMBL30852830 | 0.79 | MMP2 (0.55) | HTTALDH1A1KDM4EMMP2MMP12 | |
| SCHEMBL1777897 | 0.79 | FFAR1 (0.52) | HTTFFAR1EGLN1L3MBTL1CA12 | |
| SCHEMBL31277654 | 0.77 | HTT (0.57) | HTTGAAALDH1A1CYP1A2KDM4E | |
| SCHEMBL1276464 | 0.76 | CYP1A2 (0.56) | HTTALDH1A1CYP1A2KDM4EMMP2 | |
| SCHEMBL6446075 | 0.75 | FFAR1 (0.50) | HTTALDH1A1CYP1A2KDM4EMMP2 | |
| SCHEMBL22556202 | 0.74 | TSHR (0.56) | HTTGAAALDH1A1CYP1A2KDM4E | |
| SCHEMBL5855294 | 0.74 | HTT (0.48) | HTTGAAALDH1A1CYP1A2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |