Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819635 | 1.00 | MEN1 (0.41) | MEN1KMT2AL3MBTL1KDM4EHTT | |
| SCHEMBL2822223 | 0.91 | MEN1 (0.40) | MEN1KMT2AL3MBTL1KDM4EHTT | |
| SCHEMBL3633815 | 0.88 | S1PR1 (0.44) | RORCSIGMAR1AGTR2S1PR1S1PR5 | |
| SCHEMBL2820787 | 0.88 | S1PR1 (0.44) | RORCSIGMAR1AGTR2S1PR1S1PR5 | |
| SCHEMBL3640878 | 0.83 | KMT2A (0.45) | MEN1KMT2AL3MBTL1KDM4EHTT | |
| SCHEMBL2820989 | 0.83 | KMT2A (0.45) | MEN1KMT2AL3MBTL1KDM4EHTT | |
| SCHEMBL2820344 | 0.82 | DPP4 (0.41) | KDM4ERORCCACNA1G | |
| SCHEMBL2817101 | 0.81 | TACR1 (0.42) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL2822326 | 0.79 | ALDH1A1 (0.39) | L3MBTL1KDM4EHTTRORCALDH1A1 | |
| SCHEMBL3639016 | 0.79 | ALDH1A1 (0.39) | L3MBTL1KDM4EHTTRORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148689-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | disclosed |