Sugi Predict

Sugi Predict / Compounds / SCHEMBL3635291

SCHEMBL3635291

SCHEMBL3635291

COc1cc([N+]2(C3CCNCC3)CCC(C)CC2)ccc1Nc1nccc(-c2c(-c3cccc(C(=O)Nc4c(F)cccc4F)c3)nc3ccccn23)n1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 13/20 0.69
▸ INSR P06213 11/20 0.69
▸ EGFR P00533 2/20 0.68
▸ ERBB2 P04626 2/20 0.68
▸ MAPK14 Q16539 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3504740 0.95 IGF1R (0.69) IGF1RINSREGFRERBB2MAPK14
SCHEMBL3506008 0.88 INSR (0.68) IGF1RINSREGFRERBB2MAPK14
SCHEMBL3504856 0.88 IGF1R (0.68) IGF1RINSREGFRERBB2MAPK14
SCHEMBL3638102 0.87 INSR (0.69) IGF1RINSREGFRERBB2MAPK14
SCHEMBL310601 0.87 INSR (0.75) IGF1RINSREGFRERBB2MAPK14
SCHEMBL3503779 0.86 INSR (0.69) IGF1RINSREGFRERBB2MAPK14
SCHEMBL3503537 0.84 IGF1R (0.66) IGF1RINSREGFRERBB2MAPK14
SCHEMBL310724 0.83 INSR (0.77) IGF1RINSREGFRERBB2MAPK14
SCHEMBL10256551 0.82 IGF1R (0.90) IGF1RINSREGFRERBB2MAPK14
SCHEMBL309813 0.81 IGF1R (1.00) IGF1RINSREGFRERBB2MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2162454-A1 IMIDAZOPYRIDINE KINASE INHIBITORS GlaxoSmithKline LLC (US) 2010-03-17 — — EP disclosed
WO-2008150799-A1 IMIDAZOPYRIDINE KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-12-11 — — WO disclosed