Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055518 | 1.00 | CCKAR (0.36) | CCKARCCKBRCCNA2CDK2CCNA1 | |
| SCHEMBL3056202 | 0.91 | GRM5 (0.36) | CCNA2CDK2CCNA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3636572 | 0.91 | LMNA (0.40) | MAPT | |
| SCHEMBL3637045 | 0.91 | GRM5 (0.36) | CCNA2CDK2CCNA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3046412 | 0.91 | LMNA (0.40) | MAPT | |
| SCHEMBL3636959 | 0.89 | HCRTR1 (0.37) | CCNA2CDK2CCNA1MEN1KMT2A | |
| SCHEMBL3048755 | 0.89 | HCRTR1 (0.37) | CCNA2CDK2CCNA1MEN1KMT2A | |
| SCHEMBL3640805 | 0.86 | HCRTR1 (0.40) | — | |
| SCHEMBL3048983 | 0.86 | HCRTR1 (0.36) | CCNA2CDK2CCNA1MEN1KMT2A | |
| SCHEMBL3053202 | 0.86 | HCRTR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | disclosed |