Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182148 | 0.80 | GRIA1 (0.46) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL5678957 | 0.80 | HSD17B10 (0.50) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL25357109 | 0.68 | SLC7A5 (0.52) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL4815808 | 0.68 | SLC7A5 (0.52) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL7924230 | 0.67 | SLC7A5 (0.60) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL9066677 | 0.67 | SLC7A5 (0.60) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL8085428 | 0.67 | SLC7A5 (0.60) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL21067436 | 0.67 | GRIA2 (0.49) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL13971424 | 0.65 | SLC7A5 (0.69) | PKMUSP2CYP3A4HSD17B10HIF1A | |
| SCHEMBL9164980 | 0.65 | SLC7A5 (0.69) | PKMUSP2CYP3A4HSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180333488-A1 | LOCAL COMPLEMENT INHIBITION FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | APELLIS PHARMACEUTICALS, INC. | 2018-11-22 | — | — | US | disclosed |
| EP-2979729-A2 | COMPSTATIN ANALOGUES FOR USE IN THE TREATMENT OF INFLAMMATORY CONDITIONS OF THE RESPIRATORY SYSTEM | Apellis Pharmaceuticals, Inc. (US) | 2016-02-03 | — | — | EP | disclosed |
| US-20140050739-A1 | LOCAL COMPLEMENT INHIBITION FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | APELLIS PHARMACEUTICALS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8580735-B2 | Local complement inhibition for treatment of complement-mediated disorders | APELLIS PHARMACEUTICALS, INC. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20100166862-A1 | Local Complement Inhibition for Treatment of Complement-Mediated Disorders | POTENTIA PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| EP-2148691-A2 | LOCAL COMPLEMENT INHIBITION FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | Potentia Pharmaceuticals, Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008097525-A2 | LOCAL COMPLEMENT INHIBITION FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | POTENTIA PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |