Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5678957 | 0.83 | HSD17B10 (0.50) | GRIA1GRIA3PKMMAPTUSP2 | |
| SCHEMBL3635833 | 0.80 | PKM (0.44) | GRIA1GRIA3PKMMAPTUSP2 | |
| SCHEMBL12869089 | 0.74 | GABRA1 (0.34) | — | |
| SCHEMBL6422740 | 0.71 | GRIA1 (0.49) | GRIA1GRIA3PKMMAPTUSP2 | |
| SCHEMBL25357109 | 0.70 | SLC7A5 (0.52) | GRIA1GRIA3PKMUSP2ALDH1A1 | |
| SCHEMBL4815808 | 0.70 | SLC7A5 (0.52) | GRIA1GRIA3PKMUSP2ALDH1A1 | |
| SCHEMBL4628266 | 0.70 | CPB2 (0.56) | GRIA1GRIA3PKMMAPTUSP2 | |
| SCHEMBL8812980 | 0.69 | GRIA1 (0.71) | GRIA1GRIA3MAPTCYP2C9MEN1 | |
| SCHEMBL8812978 | 0.69 | GRIA1 (0.71) | GRIA1GRIA3MAPTCYP2C9MEN1 | |
| SCHEMBL1208452 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426114-A | Administering to treat dysfunction in excitatory amino acid neurotransmission | GUILFORD PHARMACEUTICALS INC. (US) | 1995-06-20 | — | — | US | disclosed |
| US-5331001-A | ω-[2-(tetrazolylalkyl)cyclohexyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | disclosed |