Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12489190 | 0.90 | HTT (0.47) | HTTEGFRNEK1SGK1CAMKK2 | |
| SCHEMBL926768 | 0.85 | NEK1 (0.51) | HTTNEK1AXLGABRG2GABRB3 | |
| SCHEMBL2263369 | 0.85 | PTGS1 (0.49) | HTTEGFRSGK1CAMKK2PTGS2 | |
| SCHEMBL4713912 | 0.83 | PARP1 (0.47) | HTTSGK1ALDH1A1PARP1 | |
| SCHEMBL3639904 | 0.82 | PARP1 (0.50) | SGK1CAMKK2AXLALDH1A1PARP1 | |
| SCHEMBL23163763 | 0.80 | MAPK14 (0.52) | HTTEGFRSGK1CAMKK2PTGS2 | |
| SCHEMBL8963513 | 0.80 | TSHR (0.53) | HTTEGFRNEK1SGK1CAMKK2 | |
| SCHEMBL924667 | 0.79 | AXL (0.49) | HTTNEK1TSHRAXLGABRG2 | |
| SCHEMBL543934 | 0.77 | NOTUM (0.47) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL10945978 | 0.76 | ALDH1A1 (0.52) | HTTEGFRNEK1SGK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3096758-A1 | SUBSTITUTED N-ARYL PYRIDINONES | Auspex Pharmaceuticals, Inc. (US) | 2016-11-30 | — | — | EP | disclosed |
| WO-2015112701-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-07-30 | — | — | WO | disclosed |
| EP-2170828-A1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | Auspex Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157786-A1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | AUSPEX PHARMACEUTICAL, INC. (US) | 2008-12-24 | — | — | WO | disclosed |