Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300127 | 0.91 | DRD3 (0.36) | PTGESDRD2DRD3KCNH2CTSD | |
| SCHEMBL29439602 | 0.78 | TRPV4 (0.43) | ARCYP11B1CYP11B2 | |
| SCHEMBL80153 | 0.78 | TRPV4 (0.43) | ARCYP11B1CYP11B2 | |
| SCHEMBL3639193 | 0.76 | CYP11B1 (0.34) | FFAR1ARCYP11B1CYP11B2 | |
| SCHEMBL9496967 | 0.73 | TRPV4 (0.39) | PTGESBACE1FFAR1ARCYP11B1 | |
| SCHEMBL9496961 | 0.73 | TRPV4 (0.39) | PTGESBACE1FFAR1ARCYP11B1 | |
| SCHEMBL31424271 | 0.72 | KDM1A (0.39) | KCNH2CTSDBACE1BACE2FFAR1 | |
| SCHEMBL9497108 | 0.71 | TRPV4 (0.35) | PTGESFFAR1P2RY6ARCYP11B1 | |
| SCHEMBL9497103 | 0.71 | TRPV4 (0.35) | PTGESFFAR1P2RY6ARCYP11B1 | |
| SCHEMBL21258035 | 0.71 | FFAR1 (0.47) | KCNH2FFAR1P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |