Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107836 | 0.85 | TSHR (0.58) | CYP2A13KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1427530 | 0.83 | TSHR (0.61) | CYP2A13KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3641216 | 0.81 | KDM4E (0.56) | CYP2A13KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL110887 | 0.81 | CYP2A13 (0.71) | CYP2A13ALDH1A1L3MBTL1SIGMAR1 | |
| SCHEMBL29173732 | 0.81 | KDM4E (0.64) | CYP2A13KDM4EALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL3637621 | 0.81 | KDM4E (0.56) | CYP2A13KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2800286 | 0.78 | KMT2A (0.46) | CYP2A13KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4103976 | 0.76 | CYP2A13 (1.00) | CYP2A13KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1427327 | 0.75 | KDM4E (1.00) | CYP2A13KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL5700007 | 0.72 | CCR5 (0.80) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678020-B | Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of Janus kinases | NOVARTIS AG | 2012-08-15 | — | — | CN | disclosed |
| CN-101678020-A | Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of Janus kinases | NOVARTIS AG | 2010-03-24 | — | — | CN | disclosed |
| EP-2155201-A2 | QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES | Novartis Ag (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148867-A2 | QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES | NOVARTIS AG (CH) | 2008-12-11 | — | — | WO | disclosed |