Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CALML3 | P27482 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634394 | 0.91 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL3629692 | 0.89 | HPGD (0.33) | MAOBMAOAHPGDKCNH2ALDH1A1 | |
| SCHEMBL16986061 | 0.82 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL3635376 | 0.82 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL3634497 | 0.80 | KCNH2 (0.34) | HPGDKCNH2 | |
| SCHEMBL1223138 | 0.80 | KCNH2 (0.36) | MAOBMAOACALML3KCNH2ALDH1A1 | |
| SCHEMBL1223137 | 0.80 | KCNH2 (0.36) | MAOBMAOACALML3KCNH2ALDH1A1 | |
| SCHEMBL591214 | 0.79 | GRM2 (0.35) | KCNH2 | |
| SCHEMBL591227 | 0.79 | GRM2 (0.35) | KCNH2 | |
| SCHEMBL591465 | 0.79 | GRM2 (0.35) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158199-A1 | PIPERIDINE COMPOUNDS AND USES THEREOF | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | claimed |
| WO-2008152418-A1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | WO | claimed |