Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734491 | 0.83 | GPBAR1 (0.52) | GPBAR1ALDH1A1L3MBTL1GHSRKDM4E | |
| SCHEMBL13734803 | 0.82 | LMNA (0.57) | GPBAR1ALDH1A1L3MBTL1NR1H4KDM4E | |
| SCHEMBL1179604 | 0.80 | NR1H4 (0.53) | GPBAR1ALDH1A1L3MBTL1NR1H4KDM4E | |
| SCHEMBL3637179 | 0.80 | NR1H4 (0.43) | ALDH1A1L3MBTL1NR1H4HSD17B13 | |
| SCHEMBL2776107 | 0.80 | GPBAR1 (0.43) | GPBAR1ALDH1A1L3MBTL1NR1H4KDM4E | |
| SCHEMBL29556452 | 0.78 | NR1H4 (0.55) | NR1H4HSD17B13 | |
| SCHEMBL1095858 | 0.78 | NR1H4 (0.55) | NR1H4HSD17B13 | |
| SCHEMBL2774747 | 0.76 | GPBAR1 (0.53) | GPBAR1ALDH1A1L3MBTL1GHSRKDM4E | |
| SCHEMBL13732616 | 0.73 | GPBAR1 (0.51) | GPBAR1ALDH1A1L3MBTL1NR1H4GHSR | |
| SCHEMBL21715606 | 0.72 | NR1H4 (0.54) | NR1H4HSD17B13HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |