Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637982 | 1.00 | BAZ2A (0.45) | BAZ2AIKBKBSLC6A2SLC6A4KCNH2 | |
| SCHEMBL2308254 | 0.79 | GAA (0.50) | BAZ2ASMN1; SMN2CPT2CPT1AKDM4E | |
| SCHEMBL2308250 | 0.79 | GAA (0.50) | BAZ2ASMN1; SMN2CPT2CPT1AKDM4E | |
| SCHEMBL2305542 | 0.78 | CYP19A1 (0.47) | BAZ2ASMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL2305535 | 0.78 | CYP19A1 (0.47) | BAZ2ASMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL2308438 | 0.78 | HPGDS (0.49) | BAZ2AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2308432 | 0.78 | HPGDS (0.49) | BAZ2AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2304431 | 0.77 | CPT2 (0.51) | BAZ2AIKBKBCYP1A2CPT2CPT1A | |
| SCHEMBL2304427 | 0.77 | CPT2 (0.51) | BAZ2AIKBKBCYP1A2CPT2CPT1A | |
| SCHEMBL13209703 | 0.77 | HPGDS (0.43) | BAZ2ASMN1; SMN2NPC1RAB9ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155738-A1 | PIPERIDINE-AMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008145596-A1 | PIPERIDINE-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-04 | — | — | WO | disclosed |