Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667189 | 0.83 | SMN1; SMN2 (0.57) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL3667489 | 0.81 | F2RL3 (0.54) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL12997562 | 0.80 | SMN1; SMN2 (0.57) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL3640832 | 0.79 | CYP19A1 (0.48) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL1986921 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL1691406 | 0.77 | TP53 (0.57) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL22893462 | 0.77 | TP53 (0.61) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL22893463 | 0.77 | CYP19A1 (0.51) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11030523 | 0.76 | TP53 (0.59) | F2RL3SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL1691500 | 0.75 | CYP19A1 (0.57) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167508-A1 | COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY | Summit Corporation Plc (GB) | 2010-03-31 | — | — | EP | claimed |
| WO-2009013477-A1 | COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-01-29 | — | — | WO | claimed |
| EP-2167508-A1 | COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY | Summit Corporation Plc (GB) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009013477-A1 | COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-01-29 | — | — | WO | disclosed |