SCHEMBL3667489

SCHEMBL3667489

Cc1cn2cc(-c3cccc(Cl)c3)nc2s1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 1/20 0.54
CYP19A1 P11511 1/20 0.47
TP53 P04637 5/20 0.43
SMN1; SMN2 Q16637 4/20 0.43
MAPT P10636 3/20 0.43
THRB P10828 1/20 0.43
KMT2A Q03164 1/20 0.43
NPC1 O15118 1/20 0.42
GAA P10253 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
TLR8 Q9NR97 1/20 0.42
APP P05067 1/20 0.42
PDE10A Q9Y233 1/20 0.42
TSHR P16473 1/20 0.41
ABL1 P00519 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3667189 0.82 SMN1; SMN2 (0.57) F2RL3CYP19A1TP53SMN1; SMN2MAPT
SCHEMBL11030523 0.82 TP53 (0.59) F2RL3CYP19A1TP53SMN1; SMN2MAPT
SCHEMBL3638475 0.81 F2RL3 (0.53) F2RL3CYP19A1TP53SMN1; SMN2MAPT
SCHEMBL44780 0.79 ALDH1A1 (0.44) CYP19A1TP53SMN1; SMN2MAPTKMT2A
SCHEMBL3640832 0.78 CYP19A1 (0.48) CYP19A1TP53SMN1; SMN2MAPTTHRB
SCHEMBL44483 0.78 RAB9A (0.52) TP53SMN1; SMN2MAPTTHRBKMT2A
SCHEMBL1691500 0.77 CYP19A1 (0.57) CYP19A1TP53SMN1; SMN2MAPTKMT2A
SCHEMBL44333 0.77 L3MBTL1 (0.58) CYP19A1TP53SMN1; SMN2MAPTTHRB
SCHEMBL45795 0.76 CHRM3 (0.49) TP53SMN1; SMN2MAPTGAALMNA
SCHEMBL3668799 0.75 TP53 (0.70) F2RL3TP53SMN1; SMN2MAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2167508-A1 COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY Summit Corporation Plc (GB) 2010-03-31 EP claimed
WO-2009013477-A1 COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2009-01-29 WO claimed
EP-2167508-A1 COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY Summit Corporation Plc (GB) 2010-03-31 EP disclosed
WO-2009013477-A1 COMPOUNDS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2009-01-29 WO disclosed