Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640489 | 0.89 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL3363005 | 0.88 | HCRTR1 (0.43) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3640876 | 0.87 | HCRTR1 (0.66) | HCRTR1HCRTR2 | |
| SCHEMBL3638696 | 0.87 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL1398709 | 0.87 | HCRTR1 (0.65) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL1398720 | 0.87 | HCRTR1 (0.65) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL1398735 | 0.87 | HCRTR1 (0.65) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3639860 | 0.86 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL3635222 | 0.86 | HCRTR1 (0.56) | HCRTR1HCRTR2 | |
| SCHEMBL3014848 | 0.86 | HCRTR1 (0.53) | HCRTR1HCRTR2TSPOOPRK1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | claimed |
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | disclosed |