Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butyrolactone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyrolactone SCHEMBL7686323 | 0.95 | CA1 (0.67) | CA1CA9LMNAALDH1A1TP53 | |
| Butyrolactone SCHEMBL25427151 | 0.95 | CA1 (0.67) | CA1CA9LMNAALDH1A1TP53 | |
| Bicarbonate SCHEMBL11845512 | 0.91 | CA1 (0.70) | CA1CA9LMNAALDH1A1TP53 | |
| Butyrolactone SCHEMBL5608747 | 0.90 | — | — | |
| Bicarbonate SCHEMBL2495473 | 0.88 | CA1 (0.80) | CA1CA9LMNAALDH1A1TP53 | |
| Bicarbonate SCHEMBL6753674 | 0.88 | CA1 (0.80) | CA1CA9LMNAALDH1A1TP53 | |
| Butyrolactone SCHEMBL10999881 | 0.86 | CA1 (0.61) | CA1CA9LMNAALDH1A1TP53 | |
| Butyrolactone SCHEMBL28099382 | 0.86 | CA1 (0.61) | CA1CA9LMNAALDH1A1TP53 | |
| Bicarbonate SCHEMBL8606312 | 0.86 | CA1 (0.76) | CA1CA9LMNAALDH1A1TP53 | |
| Butyrolactone SCHEMBL6571306 | 0.86 | CA1 (0.61) | CA1CA9LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017171652-A1 | PROCESS FOR THE DEPOLYMERIZATION OF LIGNIN UNDER NEUTRAL OXIDATIVE CONDITIONS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-10-05 | — | — | WO | claimed |
| US-5045159-A | Derivatives of compounds containing a carbonyl group conjugated to an aromatic moiety and electrophilic methods of fabrication thereof | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1991-09-03 | — | — | US | claimed |
| EP-2164648-A1 | LOW K DIELECTRIC | Sba Materials, Inc. (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008156680-A1 | LOW K DIELECTRIC | SBA MATERIALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| US-5003021-A | Gelation Inhibition | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1991-03-26 | — | — | US | disclosed |
| US-4251605-A | FOR BATTERIES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-02-17 | — | — | US | disclosed |
| US-4177150-A | IMPROVED MECHANICAL PROPERTIES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1979-12-04 | — | — | US | disclosed |