Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 19/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639052 | 0.94 | NR1H4 (0.66) | NR1H4 | |
| SCHEMBL3639127 | 0.94 | NR1H4 (0.65) | NR1H4TDP1L3MBTL1VDR | |
| SCHEMBL3641513 | 0.92 | NR1H4 (0.77) | NR1H4VDR | |
| SCHEMBL1179725 | 0.89 | NR1H4 (0.83) | NR1H4 | |
| SCHEMBL3644100 | 0.88 | NR1H4 (0.66) | NR1H4TDP1L3MBTL1 | |
| SCHEMBL3642158 | 0.87 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL3644591 | 0.85 | NR1H4 (0.77) | NR1H4VDR | |
| SCHEMBL3637272 | 0.83 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL1180824 | 0.83 | NR1H4 (0.83) | NR1H4 | |
| SCHEMBL1180458 | 0.82 | NR1H4 (0.83) | NR1H4VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |