Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.77 |
| ▸ | LIFR | P42702 | 2/20 | 0.51 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.49 |
| ▸ | VDR | P11473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3642158 | 0.94 | NR1H4 (0.78) | NR1H4LIFRHSD17B13 | |
| SCHEMBL3644591 | 0.94 | NR1H4 (0.77) | NR1H4LIFRHSD17B13VDR | |
| SCHEMBL3638778 | 0.92 | NR1H4 (0.65) | NR1H4VDR | |
| SCHEMBL3641386 | 0.88 | NR1H4 (0.75) | NR1H4LIFRHSD17B13 | |
| SCHEMBL3637110 | 0.88 | NR1H4 (0.78) | NR1H4LIFRHSD17B13 | |
| SCHEMBL1180127 | 0.87 | NR1H4 (1.00) | NR1H4LIFR | |
| SCHEMBL3639052 | 0.87 | NR1H4 (0.66) | NR1H4LIFRHSD17B13 | |
| SCHEMBL3639127 | 0.85 | NR1H4 (0.65) | NR1H4VDR | |
| SCHEMBL3640492 | 0.84 | NR1H4 (0.75) | NR1H4LIFRHSD17B13 | |
| SCHEMBL4952961 | 0.84 | NR1H4 (0.77) | NR1H4LIFRHSD17B13VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | claimed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | claimed |
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |