Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.82 |
| ▸ | BCL2 | P10415 | 4/20 | 0.81 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.81 |
| ▸ | BAD | Q92934 | 4/20 | 0.81 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MME | P08473 | 2/20 | 0.71 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.71 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | CRHBP | P24387 | 1/20 | 0.67 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.67 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678079 | 1.00 | MAPT (0.82) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL3638794 | 1.00 | MAPT (0.82) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL19430434 | 0.90 | MAPT (1.00) | MAPTBCL2BCL2L2BADMEN1 | |
| SCHEMBL13748183 | 0.89 | MCL1 (1.00) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL19134409 | 0.88 | MAPT (0.82) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL19430430 | 0.88 | MAPT (0.82) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL28520078 | 0.85 | BCL2L2 (0.73) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL28520077 | 0.85 | BCL2L2 (0.73) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL13846498 | 0.84 | MAPT (0.87) | MAPTBCL2BCL2L2BADMCL1 | |
| SCHEMBL25198109 | 0.81 | BCL2L2 (0.82) | MAPTBCL2BCL2L2BADMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415393-B2 | Anti-bacterial drug targeting of genome maintenance interfaces | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-09 | — | — | US | disclosed |
| EP-2178532-A2 | ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES | Wisconsin Alumni Research Foundation (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090203754-A1 | ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2009-08-13 | — | — | US | disclosed |
| WO-2009023343-A2 | ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203754-A1 | ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES | DDB1, DCLRE1B, POLM | MAPT 4348/4885BCL2 2971/4885BCL2L2 2290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.