Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 7/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30280111 | 0.78 | USP2 (0.36) | RORCNR1H2 | |
| SCHEMBL4298384 | 0.78 | CETP (0.41) | MAPTRORCGPR119POLBTACR1 | |
| SCHEMBL4298380 | 0.78 | CETP (0.41) | MAPTRORCGPR119POLBTACR1 | |
| SCHEMBL1595315 | 0.77 | NR1H2 (0.39) | MAPTRORCGPR119POLBP2RY14 | |
| SCHEMBL1594437 | 0.77 | NR1H2 (0.39) | MAPTRORCGPR119POLBP2RY14 | |
| SCHEMBL3641741 | 0.76 | MAPT (0.40) | MAPTRORCGPR119POLBTGFBR1 | |
| SCHEMBL3641743 | 0.76 | MAPT (0.40) | MAPTRORCGPR119POLBTGFBR1 | |
| SCHEMBL22059421 | 0.70 | RORC (0.57) | MAPTRORCGPR119P2RY14TACR1 | |
| SCHEMBL1294818 | 0.68 | USP2 (0.39) | NR1H2 | |
| SCHEMBL18138321 | 0.68 | USP2 (0.39) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167504-A2 | THIADIAZOLE MODULATORS OF PKB | Amgen, Inc (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009011871-A2 | THIADIAZOLE MODULATORS OF PKB | AMGEN INC. (US) | 2009-01-22 | — | — | WO | disclosed |