Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993785 | 0.87 | PTGDR2 (0.35) | PTGDR2KMT2ATSHRKDM4EGPR119 | |
| SCHEMBL2987768 | 0.73 | PTGDR2 (0.32) | PTGDR2 | |
| SCHEMBL16036262 | 0.73 | KIT (0.46) | GPR119 | |
| SCHEMBL16042208 | 0.71 | CCNT1 (0.43) | LMNAKMT2AMAPTTSHRKDM4E | |
| SCHEMBL16040328 | 0.70 | HTR6 (0.43) | PTGDR2 | |
| SCHEMBL13981341 | 0.70 | PTGDR2 (0.30) | PTGDR2 | |
| SCHEMBL13548246 | 0.69 | PTGDR2 (0.46) | PTGDR2LMNAMAPTTSHRKDM4E | |
| SCHEMBL30668847 | 0.69 | PTGDR2 (0.46) | PTGDR2LMNAMAPTTSHRKDM4E | |
| SCHEMBL3603085 | 0.69 | PTGDR2 (0.46) | PTGDR2LMNAMAPTL3MBTL1GAA | |
| SCHEMBL3412397 | 0.68 | PTGDR2 (0.47) | PTGDR2LMNATSHRKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162455-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | Glaxo Group Limited (GB) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008145688-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |