Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659077 | 0.89 | ATM (0.57) | ATML3MBTL1PDPK1HRH1CXCR4 | |
| SCHEMBL9597587 | 0.81 | ATM (0.63) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL9570129 | 0.81 | ATM (0.63) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL6115037 | 0.81 | ATM (0.63) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL3639574 | 0.80 | PDPK1 (0.54) | ATML3MBTL1PDPK1CXCR4KDM4C | |
| SCHEMBL9570312 | 0.80 | ATM (0.61) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL9598426 | 0.80 | ATM (0.61) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL3347670 | 0.80 | L3MBTL1 (0.61) | ATML3MBTL1PDPK1KDM4CCYP2A6 | |
| SCHEMBL6115288 | 0.79 | ATM (0.59) | ATML3MBTL1KDM4CCYP2A6CYP1A2 | |
| SCHEMBL6114489 | 0.79 | ATM (0.59) | ATML3MBTL1KDM4CCYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155751-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |