Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.54 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | CLK2 | P49760 | 3/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.48 |
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673923 | 0.95 | MLLT3 (0.60) | TSHRROCK2GSK3BPIM1MLLT3 | |
| SCHEMBL3668493 | 0.86 | ROCK2 (0.58) | TSHRROCK2GSK3BPIM1MLLT3 | |
| SCHEMBL3669097 | 0.82 | ROCK2 (0.65) | ROCK2GSK3BPIM1MLLT3MLLT1 | |
| SCHEMBL14863654 | 0.82 | HTT (0.60) | TSHRTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL14863655 | 0.82 | HTT (0.60) | TSHRTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL3634686 | 0.81 | ROCK2 (0.58) | ROCK2GSK3BPIM1MLLT3MLLT1 | |
| SCHEMBL4298241 | 0.81 | ROCK2 (0.58) | ROCK2GSK3BPIM1MLLT3MLLT1 | |
| SCHEMBL3636521 | 0.81 | ROCK2 (0.58) | ROCK2GSK3BPIM1MLLT3MLLT1 | |
| SCHEMBL3670760 | 0.80 | ROCK2 (0.67) | ROCK2GSK3BPIM1MLLT3MLLT1 | |
| SCHEMBL13901930 | 0.78 | ROCK2 (0.67) | ROCK2GSK3BPIM1MLLT3MLLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | claimed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | claimed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | claimed |
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8648069-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | TSHR 3823/4885ROCK2 48/4885GSK3B 1/4885 |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | TSHR 3823/4885ROCK2 48/4885GSK3B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.