Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336905 | 0.83 | KDM4E (0.42) | KDM4EHSD17B10ALDH1A1PTGER4GAA | |
| SCHEMBL3638353 | 0.82 | KDM4C (0.44) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL27785056 | 0.81 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1PTGER4GAA | |
| SCHEMBL19689691 | 0.79 | KMT2A (0.49) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL13921285 | 0.77 | CLCN2 (0.49) | KDM4EALDH1A1GAAHPGDCLCN2 | |
| SCHEMBL7745707 | 0.77 | PTGER4 (0.47) | KDM4EHSD17B10ALDH1A1PTGER4GAA | |
| SCHEMBL18272540 | 0.76 | PTGER4 (0.56) | KDM4EALDH1A1PTGER4GAAHPGD | |
| SCHEMBL15638826 | 0.75 | GRIK1 (0.46) | KDM4EHSD17B10ALDH1A1GAAHPGD | |
| SCHEMBL590235 | 0.75 | RXFP1 (0.41) | KDM4EHSD17B10ALDH1A1PTGER4LMNA | |
| SCHEMBL18669314 | 0.74 | PTGER4 (0.58) | KDM4EHSD17B10ALDH1A1PTGER4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |